The activities of the Research Center are structured through five Research Departments, each with its own Scientific Research Areas, as well as Third Mission and Advanced Training objectives, specifically:
| Department of Research on Education, Innovation, Diplomacy Area Dipartimentale Cybersecurity | Director Prof. Laura Mazza Director Prof. Giuseppe Izzo |
| Dipartimento PPAN Academy | General Director Prof. Andrea Nonni Exec. Director: Prof.Paola Pierotti |
| Department of Digital & Law | General Director: Avv. Andrea Lisi Exec. Director: Prof. Giuseppe Gimigliano |
| Department of Advanced Studies in Geopolitics, Law and Public Policies | Director Sen. Marco Scurria |
| Department of Human-centric Digital Transformation and Ethical Innovation Marketing Management – DiTEIM | Director ad interim / hidden content |